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2 edition of Alterations in the circulating CD5+ B-cell population in bovine leukemia virus infected sheep found in the catalog.

Alterations in the circulating CD5+ B-cell population in bovine leukemia virus infected sheep

Ted Alan Birkebak

Alterations in the circulating CD5+ B-cell population in bovine leukemia virus infected sheep

by Ted Alan Birkebak

  • 70 Want to read
  • 38 Currently reading

Published .
Written in English

    Subjects:
  • Bovine leukemia virus.,
  • Sheep -- Diseases -- Immunology.,
  • B cells.

  • Edition Notes

    Statementby Ted Alan Birkebak.
    The Physical Object
    Paginationviii, 55 leaves, bound :
    Number of Pages55
    ID Numbers
    Open LibraryOL17002344M

    Bovine leukemia virus (BLV) is a B-lymphotropic retrovirus that is associated with B-cell lymphoproliferative disorders in cattle (2, 22).Infection can either remain asymptomatic or result in persistent lymphocytosis, characterized by an increased number of circulating B lymphocytes and, more rarely, by clonal lymphoid tumors after a long latency by: The Bovine Leukemia Virus system. The Bovine Leukemia Virus (BLV) shares structural homologies with HTLV BLV transforms bovine and ovine B lymphocytes and induces monoclonal leukemia/lymphoma (malignant lymphoma) in % of infected sheep with an average latency of 30 months.

    Willems L, Kettmann R, Dequiedt F, et al. In vivo infection of sheep by bovine leukemia virus mutants. J Virol. ;67(7)– Boris-Lawrie K, Temin HM. Genetically simpler bovine leukemia virus derivatives can replicate independently of Tax and Rex. J Virol. ;69(3)– Cited by: 4. Bovine leukemia virus (BLV) infection induces bovine leukemia in cattle and causes significant financial harm to farmers and farm management. There is no effective therapy or vaccine; thus, the diagnosis and elimination of BLV-infected cattle are Cited by: 4.

    Bovine leukemia virus (BLV), a deltaretrovirus, causes B-cell leukemia/lymphoma in cattle and is prevalent in herds globally. A previous finding of antibodies against BLV in humans led us to examine the possibility of human infection with BLV. We focused on breast tissue because, in cattle, BLV DNA and protein have been found to be more abundant in mammary epithelium . Bovine leukemia virus (BLV), a deltaretrovirus, causes B-cell leukemia/lymphoma in cattle and is prevalent in herds globally. A previous finding of antibodies against BLV in humans led us to examine the possibility of human infection with BLV. We focused on breast tissue because, in cattle, BLV DNA and protein have been found to be more Cited by:


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Alterations in the circulating CD5+ B-cell population in bovine leukemia virus infected sheep by Ted Alan Birkebak Download PDF EPUB FB2

Leukemia. May;4(5) B cells from bovine leukemia virus- (BLV) infected sheep with hematological disorders express the CD5 T cell marker. Letesson JJ(1), Mager A, Mammerickx M, Burny A, Depelchin A. Author information: (1)Microbiology and Immunology Unit, Universite Notre Dame de la Paix Namur, by: In cattle, B-cell lymphocytosis results from an increased number of circulating CD5 + B lymphocytes (6, 18, 19) associated with a lower but significant increase of the CD5 − B-cell population, whereas lymphomas appear to arise exclusively from the CD5 + B-cell by: Association of GP51 expression and persistent CD5+ B-lymphocyte expansion with lymphomagenesis in bovine leukemia virus infected sheep.

Leukemia. Nov; 8 (11)– Brenner J, Van-Haam M, Savir D, Trainin Z. The implication of BLV infection in the productivity, reproductive capacity and survival rate of a dairy by: CD5+ B cells from bovine leukemia virus infected cows are activated cycling cells responsive to interleukin 2 Article (PDF Available) in Leukemia 6(4) May with 40 Reads.

Quantitative characterization of the circulating CD5+ lymphocyte population in sheep was performed using monoclonal antibodies against ovine CD5, ovine CD2, and ovine sIgM. A total of fifteen sheep were examined biweekly over a period of by: 9.

antigen detected on BLV-infected cells could be the bovine counterpart of the CD5 antigen. By another way, it has been found that the CD5 T cell antigen is also present on a minor subpopulation of B cells in the spleen but not in the blood. We suggest that in the bovine a similar B cell subpopulation should be the BLVCited by:   In addition to these markers pertaining to B lymphocytes, infected cells frequently co-express the CD5 molecule.

B cell lymphocytosis essentially results from an increased proliferation of circulating CD5+ B lymphocytes associated with a lower but significant increase of the CD5- B cell population [, ].Cited by: All together, a large body of evidence supports widespread immune dysfunction in BLV-infected animals (summarized in Table 1), although little research has been done to investigate the impact this dysfunction has on bovine health and deficit is likely due to the belief that BLV infection is only detrimental in the small proportion of animals that develop either leukemia Cited by:   Bovine leukemia virus (BLV) is associated with enzootic bovine leukosis, which is the most common neoplastic disease of cattle.

BLV infects cattle worldwide, imposing a severe economic impact on the dairy cattle industry. Recently, we developed a new quantitative real-time polymerase chain reaction (PCR) method using Coordination of Common Motifs (CoCoMo) Cited by: Estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis using BLV.

B cell lymphocytosis essentially results from an increased proliferation of circulating CD5+ B lymphocytes associated with a lower but significant increase of the CD5- B cell population [–]. Although the provirus has been detected in both CD5+ and CD5- B lymphocytes from infected animals, lymphosarcoma cells appear to exhibit mainly, but not exclusively, the CD5+ B phenotype Cited by: CD5 – B cells from the four BLV-infected sheep (W, W, G, and B) represented a decrease in apoptosis compared with the two uninfected sheep (Ki-2 and Or): the apoptotic rates of PBMCs from the BLV-infected sheep with PL (% ± % and ± % for G and B, respectively) were greatly decreased compared with those of BLV-infected but Cited by:   A study to investigate the types and distribution of bovine leukemia virus (BLV) was conducted on about eight hundred cattle drawn from 53 farms found in 16 prefectures in Japan.

Agar gel immunodiffusion (AGID) tests of serum samples and nested-PCR to detect BLV provirus, in peripheral blood leukocytes were performed.

To identify genotypes, restriction Cited by: Apoptosis of CD5+ cells and lymphocyte proliferation in bovine leukemia virus-infected dairy cows Article (PDF Available) in Arquivo Brasileiro de Medicina Veterinária e Zootecnia 63(5) Background: Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T cell leukemia virus-1 (HTLV-1).

Cattle are the natural host of BLV where it integrates into B-cells, producing a lifelong infection. Most infected animals remain asymptomatic but following a protracted latency period about 5 % develop an aggressive leukemia/Cited by: v ol.

80, b-cell death and homeostasis in blv-infected sheep DEBACQ ET AL. V IROL. of peripheral blood B cells labeled by the initial injection. Bovine leukemia virus (BLV) is the etiologic agent of enzootic bovine leukosis (EBL). In a previous report, we found that in a sheep model, only CD5(-) B cells proliferated clonally, while CD5(+) B.

This study used a combination of single antigen immunoperoxidase staining for bovine leukaemia virus (BLV) p24 capsid antigen and IgM to enumerate the peripheral blood mononuclear cells (PBMCs) infected with BLV and the number of B-cells, respectively. A significant relationship was found between the number of BLV-infected PBMCs and the number of circulating Cited by: 6.

In 16 cases, the neoplastic cells were characterized by. a marked variation in cell size, atypia in large cells, nuclear irregularity in smaller cells, and nucleolar. prominence in cells with scant cytoplasm. Vet Microbiol ; 2.

Aida Y, Miyaska M, Okada K et al. Further phenotypic characterization of target cells for bovine leukemia virus experimental infection in sheep. Am J Vet Res ; 3. Williams DL, Barta 0, Amborski G. Molecular studies of T-lymphocytes from cattle infected with bovine leukemia by:.

5. Buehring GC, et al. Bovine leukemia virus DNA in human breast tissue. Emerg. Infec. Dis6. Erskine RJ, et al. Association between bovine leukemia virus, production, and population age in Michigan dairy herds.

J Dairy Sci7. Evermann JF, et al. Transmission of bovine leukosis virus by blood inoculation.Bovine leukemia virus (BLV) is an oncogenic retrovirus associated with B-cell lymphocytosis, leukemia, and lymphosarcoma in the ovine and bovine species.

We have recently reported that in sheep, BLV protects the total population of peripheral blood mononuclear cells (PBMCs) from ex vivo spontaneous apoptosis. Bovine leukemia virus (BLV) is a member of the genus Deltaretrovirus (subfamily Orthoretrovirinae, family Retroviridae) and is genetically related to human T-cell leukemia virus type 1 [].BLV infects B cells in cattle and is integrated into the host genome as a provirus [2, 3].The majority (around 70%) of BLV infections in cattle remain clinically asymptomatic, Cited by: 5.